Perioperative chemotherapy in the treatment of locally advanced forms of colon cancer: literature review

Neoadjuvant systemic therapy is standard of care for many tumors, especially gastrointestinal ones. has potential advantages, including tumor downstaging, early treatment micrometastatic disease and possibility to evaluate biology in order personalize treatment. Currently, perioperative chemotherapy isn’t the advanced colon cancer. Limitations widespread use have included inaccurate radiological staging, concerns about progression a lack randomized data.